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Article

Application of high-resolution single-channel recording to functional studies of cystic fibrosis mutants.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011

Cai Zhiwei, Sohma Yoshiro, Bompadre Silvia G, Sheppard David N, Hwang Tzyh-Chang

Abstract excerpt

The patch-clamp technique is a powerful and versatile method to investigate the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, its malfunction in disease and modulation by small molecules. Here, we discuss how the molecular behaviour of CFTR is investigated using high-resolution single-channel recording and kinetic analyses of channel gating. We review methods used to quantify how cystic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21594800
DOI: 10.1007/978-1-61779-117-8_27
PMCID: PMC4939242

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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