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Article

Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.

The Journal of physiology - 1 Jun 2015

Cai Zhiwei, Palmai-Pallag Timea, Khuituan Pissared, Mutolo Michael J, Boinot Clément, Liu Beihui, Scott-Ward Toby S, Callebaut Isabelle, Harris Ann, Sheppard David N

Abstract excerpt

KEY POINTS: Malfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), a gated pathway for chloride movement, causes the common life-shortening genetic disease cystic fibrosis (CF). Towards the development of a sheep model of CF, we have investigated the function of sheep CFTR. We found that sheep CFTR was noticeably more active than human CFTR, while the most common CF mutation, F508del, had...

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Identifiers

PMID: 25763566
DOI: 10.1113/JP270227
PMCID: PMC4461407

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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