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Article

A Conserved Region of the R Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is Important in Processing and Function

1 Nov 1998

Abstract excerpt

The R domain of cystic fibrosis transmembrane conductance regulator (CFTR) connects the two halves of the protein, each of which possess a transmembrane-spanning domain and a nucleotide binding domain. Phosphorylation of serine residues, which reside mostly within the C-terminal two-thirds of the R domain, is required for nucleotide-dependent activation of CFTR chloride channel activity. The N terminus of the R...

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PMID: 9822639
DOI: 10.1074/jbc.273.48.31759

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A Conserved Region of the R Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is Important in Processing and FunctionPMID 9822639Read ↗

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Disease-associated mutations in the fourth cytoplasmic loop of cystic fibrosis transmembrane conductance regulator compromise biosynthetic processing and chloride channel activity.Semantic proximity Read ↗

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Protein Processing and Inflammatory Signaling in Cystic Fibrosis: Challenges and Therapeutic StrategiesSemantic proximity Read ↗

Phosphorylation site independent single R-domain mutations affect CFTR channel activity.Semantic proximity Read ↗

A cluster of inhibitory residues in the regulatory domain prevents activation of the cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

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