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Article

The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.

Pflugers Archiv : European journal of physiology - 1 Aug 2015

Broadbent Steven D, Ramjeesingh Mohabir, Bear Christine E, Argent Barry E, Linsdell Paul, Gray Michael A

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl(-) channel that governs the quantity and composition of epithelial secretions. CFTR function is normally tightly controlled as dysregulation can lead to life-threatening diseases such as secretory diarrhoea and cystic fibrosis. CFTR activity is regulated by phosphorylation of its cytosolic regulatory (R) domain, and ATP binding and hydrolysis...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25277268
DOI: 10.1007/s00424-014-1618-8
PMCID: PMC4502298

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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