Article
Two cystic fibrosis transmembrane conductance regulator mutations have different effects on both pulmonary phenotype and regulation of outwardly rectified chloride currents.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 1995
Fulmer S B, Schwiebert E M, Morales M M, Guggino W B, Cutting G R
Abstract excerpt
Cystic fibrosis (CF), a disorder of electrolyte transport manifest in the lungs, pancreas, sweat duct, and vas deferens, is caused by mutations in the CF transmembrane conductance regulator (CFTR). The CFTR protein has been shown to function as a cAMP-activated chloride channel and also regulates a separate protein, the outwardly rectifying chloride channel (ORCC). To determine the consequence of...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Chlorides
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Electric Conductivity
- Epithelium
- Humans
- Lung