Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The gating of the CFTR channel.

Cellular and molecular life sciences : CMLS - 1 Jan 2017

Moran Oscar

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel expressed in the apical membrane of epithelia. Mutations in the CFTR gene are the cause of cystsic fibrosis. CFTR is the only ABC-protein that constitutes an ion channel pore forming subunit. CFTR gating is regulated in complex manner as phosphorylation is mandatory for channel activity and gating is directly regulated by binding of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Cystic Fibrosis
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Ion Channel Gating

Share to Mutation

Share to Phosphorylation

Share to Protein Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 27696113
DOI: 10.1007/s00018-016-2390-z
PMCID: PMC11107742

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The gating of the CFTR channel.PMID 27696113Read ↗

Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation.Semantic proximity Read ↗

CFTR!Semantic proximity Read ↗

A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporter.Semantic proximity Read ↗

The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.Semantic proximity Read ↗

Quantitative analysis of ATP-dependent gating of CFTR.Semantic proximity Read ↗

The biogenesis, traffic, and function of the cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

CFTR regulation of epithelial sodium channel.Semantic proximity Read ↗

The cystic fibrosis gene and its product CFTR.Semantic proximity Read ↗

An intrinsic adenylate kinase activity regulates gating of the ABC transporter CFTR.Semantic proximity Read ↗

G551D and G1349D, Two CF-associated Mutations in the Signature Sequences of CFTR, Exhibit Distinct Gating DefectsSemantic proximity Read ↗

The interactome of cystic fibrosis transmembrane conductance regulator and its role in male fertility: A critical reviewSemantic proximity Read ↗

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.