Article
Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Csanády László, Vergani Paola, Gulyás-Kovács Attila, Gadsby David C
Abstract excerpt
CFTR is the only member of the ABC (ATP-binding cassette) protein superfamily known to function as an ion channel. Most other ABC proteins are ATP-driven transporters, in which a cycle of ATP binding and hydrolysis, at intracellular nucleotide binding domains (NBDs), powers uphill substrate translocation across the membrane. In CFTR, this same ATP-driven cycle opens and closes a transmembrane pore through which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.