Article
Mitochondrial AAA-type protease Yme1p is involved in Bax effects on cytochrome c oxidase.
Biochemical and biophysical research communications - 21 Dec 2001
Manon S, Priault M, Camougrand N
Abstract excerpt
Expression of the pro-apoptotic protein Bax in yeast Saccharomyces cerevisiae induces a release of cytochrome c accompanied by a decrease of the amount of cytochrome c oxidase. Here we show that the decrease of cytochrome c oxidase is due to the activation of mitochondrial protease Yme1p, of which cytochrome c oxidase subunit 2 (Cox2p) is a substrate. The absence of Yme1p slightly delays Bax-induced cell death,...
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