Article
Absence of the mitochondrial AAA protease Yme1p restores F0-ATPase subunit accumulation in an oxa1 deletion mutant of Saccharomyces cerevisiae.
The Journal of biological chemistry - 4 Aug 2000
Lemaire C, Hamel P, Velours J, Dujardin G
Abstract excerpt
The nuclear gene OXA1 encodes a protein located within the mitochondrial inner membrane that is required for the biogenesis of both cytochrome c oxidase (Cox) and ATPase. In the absence of Oxa1p, the translocation of the mitochondrially encoded subunit Cox2p to the intermembrane space (also referred to as export) is prevented, and it has been proposed that Oxa1p could be a component of a general mitochondrial...
Topics
- ATP-Dependent Proteases
- Adenosine Triphosphatases
- Electron Transport Complex IV
- Energy Metabolism
- Enzyme Stability
- Fungal Proteins
- Genes, Lethal
- Membrane Proteins
- Metalloendopeptidases
- Mitochondria
- Mitochondrial Proteins
- Mutation
- Nuclear Proteins
- Proton-Translocating ATPases