Article
Oxygen stress: a regulator of apoptosis in yeast.
The Journal of cell biology - 17 May 1999
Madeo F, Fröhlich E, Ligr M, Grey M, Sigrist S J, Wolf D H, Fröhlich K U
Abstract excerpt
Oxygen radicals are important components of metazoan apoptosis. We have found that apoptosis can be induced in the yeast Saccharomyces cerevisiae by depletion of glutathione or by low external doses of H2O2. Cycloheximide prevents apoptotic death revealing active participation of the cell. Yeast can also be triggered into apoptosis by a mutation in CDC48 or by expression of mammalian bax. In both cases, we show...
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