Oxygen stress: a regulator of apoptosis in yeast.

doi:10.1083/jcb.145.4.757

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Article

Oxygen stress: a regulator of apoptosis in yeast.

The Journal of cell biology - 17 May 1999

Madeo F, Fröhlich E, Ligr M, Grey M, Sigrist S J, Wolf D H, Fröhlich K U

Abstract excerpt

Oxygen radicals are important components of metazoan apoptosis. We have found that apoptosis can be induced in the yeast Saccharomyces cerevisiae by depletion of glutathione or by low external doses of H2O2. Cycloheximide prevents apoptotic death revealing active participation of the cell. Yeast can also be triggered into apoptosis by a mutation in CDC48 or by expression of mammalian bax. In both cases, we show...

Topics

Adenosine Triphosphatases
Apoptosis
Biomarkers
Cell Cycle Proteins
Cycloheximide
Fungal Proteins
Glutathione
Hydrogen Peroxide
Mutagenesis
Oxidative Stress
Oxygen
Phenotype
Protein Synthesis Inhibitors
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2

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Identifiers

PMID: 10330404
DOI: 10.1083/jcb.145.4.757
PMCID: PMC2133192

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Reactive Oxygen Species

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins