Article
The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc.
The Journal of nutrition - 1 Dec 2001
Morishita K, Shirai A, Kubota M, Katakura Y, Nabeshima Y, Takeshige K, Kamiya T
Abstract excerpt
Reduction in klotho gene expression causes accelerated senescence in klotho mutant mice. We have now found two key substances, phosphorus and zinc, which affect the appearance of klotho phenotypes. Klotho mutant homozygotes fed nonpurified diet with a phosphorus concentration of 1.03 g/100 g showed typical klotho phenotypes. However, most of the klotho phenotypes no longer appeared in male homozygotes fed a 0.4...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.