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Article

Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.

Endocrinology - 1 Feb 2002

Yoshida Toru, Fujimori Toshihiko, Nabeshima Yo-Ichi

Abstract excerpt

Homozygous klotho mutant (kl-/-) mice exhibit multiple phenotypes resembling human aging. To elucidate the molecular basis of these singular phenotypes, we focused on the mechanisms underlying increased serum concentrations of calcium and phosphorus in kl-/- mice. Serum concentrations of calcitonin and PTH of kl-/- mice were normally up- and down-regulated, respectively, in response to the high levels of calcium....

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Source

Identifiers

PMID: 11796525
DOI: 10.1210/endo.143.2.8657

Genes

PTH
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.PMID 11796525Read ↗

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