The Antisenescence Protein Klotho Is Necessary for FGF23-Induced Phosphaturia

Abstract excerpt

It was almost one decade ago (1) that the klotho gene had been identified, but it does not fail to still spring surprises. Mice with a defect of klotho gene expression secondary to an insertional mutation disrupting the 5′ region develop a phenotype that reproduces not only individual features of human aging, but a complex spectrum of premature senescence: short lifespan, growth retardation, infertility,...

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