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Article

Klotho and aging.

Biochimica et biophysica acta - 1 Oct 2009

Kuro-o Makoto

Abstract excerpt

The klotho gene encodes a single-pass transmembrane protein that forms a complex with multiple fibroblast growth factor (FGF) receptors and functions as an obligatory co-receptor for FGF23, a bone-derived hormone that induces negative phosphate balance. Defects in either Klotho or Fgf23 gene expression cause not only phosphate retention but also a premature-aging syndrome in mice, unveiling a potential link...

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Source

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Identifiers

PMID: 19230844
DOI: 10.1016/j.bbagen.2009.02.005
PMCID: PMC2743784

Genes

FGF23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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