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Molecular Basis of Klotho: From Gene to Function in Aging

19 Feb 2015

Abstract excerpt

The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-suppressor gene, has generated tremendous interest and has advanced understanding of the aging process. In mice, the overexpression of the KL gene extends the life span, whereas mutations to the KL gene shorten the life span. The human KL gene encodes the α-Klotho protein, which is a multifunctional protein that regulates...

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PMID: 25695404
DOI: 10.1210/er.2013-1079

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