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Article

Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers.

Circulation research - 7 Dec 2001

Steitz S A, Speer M Y, Curinga G, Yang H Y, Haynes P, Aebersold R, Schinke T, Karsenty G, Giachelli C M

Abstract excerpt

Bovine aortic smooth muscle cell (BASMC) cultures undergo mineralization on addition of the organic phosphate donor, beta-glycerophosphate (betaGP). Mineralization is characterized by apatite deposition on collagen fibrils and the presence of matrix vesicles, as has been described in calcified vascular lesions in vivo as well as in bone and teeth. In the present study, we used this model to investigate the...

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Source

Identifiers

PMID: 11739279
DOI: 10.1161/hh2401.101070

Genes

GLA
MGP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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