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Article

Cyclic strain inhibits switching of smooth muscle cells to an osteoblast-like phenotype.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2003

Nikolovski Janeta, Kim Byung-Soo, Mooney David J

Abstract excerpt

Ectopic calcification is commonly associated with cardiovascular disease, injury, aging, and biomaterial implantation. We hypothesized that the normal mechanical environment of smooth muscle cells (SMCs) inhibits a phenotypic switch to a pattern of gene expression more typical for bone and inducive for calcification. This hypothesis was tested using a 3-D engineered smooth muscle tissue model subjected to cyclic...

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PMID: 12514116
DOI: 10.1096/fj.02-0459fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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