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Article

Lyso-phosphatidylcholine induces osteogenic gene expression and phenotype in vascular smooth muscle cells.

Atherosclerosis - 1 Jul 2010

Vickers Kasey C, Castro-Chavez Fernando, Morrisett Joel D

Abstract excerpt

OBJECTIVE: Calcifying vascular cells in human atherosclerotic plaques actively contribute to ectopic vascular mineralization. Lyso-phosphatidylcholine (LPC), a product of oxidized phosphatidylcholine hydrolysis, is found at concentrations of 1-12 microg/g tissue throughout the atheroma. The objective of this study was to determine if LPC induces an osteogenic phenotype in vascular smooth muscle cells. METHODS AND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20451909
DOI: 10.1016/j.atherosclerosis.2010.04.005
PMCID: PMC2902706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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