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Article

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness.

Cardiovascular research - 15 Mar 2018

Durham Andrew L, Speer Mei Y, Scatena Marta, Giachelli Cecilia M, Shanahan Catherine M

Abstract excerpt

Vascular calcification is associated with a significant increase in all-cause mortality and atherosclerotic plaque rupture. Calcification has been determined to be an active process driven in part by vascular smooth muscle cell (VSMC) transdifferentiation within the vascular wall. Historically, VSMC phenotype switching has been viewed as binary, with the cells able to adopt a physiological contractile phenotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29514202
DOI: 10.1093/cvr/cvy010
PMCID: PMC5852633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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