Article
Transducing properties of Drosophila Frizzled proteins.
Development (Cambridge, England) - 1 Dec 2001
Strapps W R, Tomlinson A
Abstract excerpt
In Drosophila, two closely related serpentine receptors, Frizzled (Fz) and D-Frizzled2 (Fz2) are able to act as receptors for the secreted Wnt peptide, Wingless (Wg). In addition to transducing the Wg signal, Fz (but not Fz2) is able to transduce a second, unidentified signal that mediates planar polarity. Much attention has been focused on the structure of the N-termini of the Fz-class receptors and their role...
Topics
- Animals
- Body Patterning
- Drosophila
- Drosophila Proteins
- Eye
- Frizzled Receptors
- Gene Expression Regulation, Developmental
- Membrane Proteins
- Phenotype
- Proto-Oncogene Proteins
- Receptors, G-Protein-Coupled
- Receptors, Neurotransmitter
- Recombinant Fusion Proteins
- Signal Transduction
- Wings, Animal
- Wnt1 Protein
