Article
Trimeric G protein-dependent frizzled signaling in Drosophila.
Cell - 14 Jan 2005
Katanaev Vladimir L, Ponzielli Romina, Sémériva Michel, Tomlinson Andrew
Abstract excerpt
Frizzled (Fz) proteins are serpentine receptors that transduce critical cellular signals during development. Serpentine receptors usually signal to downstream effectors through an associated trimeric G protein complex. However, clear evidence for the role of trimeric G protein complexes for the Fz family of receptors has hitherto been lacking. Here, we show roles for the Galpha(o) subunit (Go) in mediating the...
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