Trimeric G protein-dependent frizzled signaling in Drosophila.

doi:10.1016/j.cell.2004.11.014

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Article

Trimeric G protein-dependent frizzled signaling in Drosophila.

Cell - 14 Jan 2005

Katanaev Vladimir L, Ponzielli Romina, Sémériva Michel, Tomlinson Andrew

Abstract excerpt

Frizzled (Fz) proteins are serpentine receptors that transduce critical cellular signals during development. Serpentine receptors usually signal to downstream effectors through an associated trimeric G protein complex. However, clear evidence for the role of trimeric G protein complexes for the Fz family of receptors has hitherto been lacking. Here, we show roles for the Galpha(o) subunit (Go) in mediating the...

Topics

Animals
Cell Polarity
Drosophila
Drosophila Proteins
Frizzled Receptors
GTP-Binding Protein alpha Subunits, Gi-Go
Green Fluorescent Proteins
Intercellular Signaling Peptides and Proteins
Membrane Proteins
Phenotype
Proto-Oncogene Proteins
Receptors, G-Protein-Coupled
Signal Transduction
Wings, Animal
Wnt Proteins
Wnt1 Protein

Source

Open in PubMed

Identifiers

PMID: 15652486
DOI: 10.1016/j.cell.2004.11.014

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