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Article

A Novel Frizzled-Based Screening Tool Identifies Genetic Modifiers of Planar Cell Polarity in Drosophila Wings.

G3 (Bethesda, Md.) - 7 Dec 2016

Carvajal-Gonzalez Jose Maria, Mulero-Navarro Sonia, Smith Michael, Mlodzik Marek

Abstract excerpt

Most mutant alleles in the Fz-PCP pathway genes were discovered in classic Drosophila screens looking for recessive loss-of-function (LOF) mutations. Nonetheless, although Fz-PCP signaling is sensitive to increased doses of PCP gene products, not many screens have been performed in the wing under genetically engineered Fz overexpression conditions, mostly because the Fz phenotypes were strong and/or not easy to...

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Identifiers

PMID: 27729438
DOI: 10.1534/g3.116.035535
PMCID: PMC5144966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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