Article
Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless.
Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2004
Chen Chiann-Mun, Strapps Walter, Tomlinson Andrew, Struhl Gary
Abstract excerpt
Members of the Frizzled family of serpentine transmembrane receptors are required to transduce Wingless/Int (Wnt) signals and contain in their N-terminal regions a conserved Wnt-binding cysteine-rich domain (CRD). Each CRD has specific affinities for particular Wnts, and it is generally believed that signal transduction depends on the strength of this interaction. Here, we report in vivo evidence that the CRD is...
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