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Article

Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons.

Neuroreport - 4 Dec 2001

Endres M, Fan G, Meisel A, Dirnagl U, Jaenisch R

Abstract excerpt

DNA methylation is important for controlling gene expression and is catalyzed by DNA methyltransferase (Dnmt1) an enzyme abundant in brain. We recently demonstrated that mice expressing reduced levels of Dnmt1 are protected from cerebral ischemia. Here, we used the cre/loxP system to produce conditional mutants that lack Dnmt 1 in postmitotic neurons of the postnatal brain. We demonstrate that animals...

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Source

Identifiers

PMID: 11726790
DOI: 10.1097/00001756-200112040-00032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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