Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation.

Neuron - 18 Sept 2013

Kaas Garrett A, Zhong Chun, Eason Dawn E, Ross Daniel L, Vachhani Raj V, Ming Guo-Li, King Jennifer R, Song Hongjun, Sweatt J David

Abstract excerpt

Dynamic changes in 5-methylcytosine (5mC) have been implicated in the regulation of gene expression critical for consolidation of memory. However, little is known about how these changes in 5mC are regulated in the adult brain. The enzyme methylcytosine dioxygenase TET1 (TET1) has been shown to promote active DNA demethylation in the nervous system. Therefore, we took a viral-mediated approach to overexpress the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Central Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Classical

Share to Cytosine

Share to Hydroxylation

Share to Memory

Share to Potassium Chloride

Share to Transduction, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 24050399
DOI: 10.1016/j.neuron.2013.08.032
PMCID: PMC3816951

Genes

TET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation.PMID 24050399Read ↗

TET1 displays catalytic and non-catalytic functions in the adult mouse cortex.Semantic proximity Read ↗

Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged MiceSemantic proximity Read ↗

TET proteins and 5-methylcytosine oxidation in the immune system.Semantic proximity Read ↗

Alterations in DNA 5-hydroxymethylation patterns in the hippocampus of an experimental model of chronic epilepsySemantic proximity Read ↗

Alterations in DNA 5-hydroxymethylation Patterns in the Hippocampus of an Experimental Model of Refractory EpilepsySemantic proximity Read ↗

Ten-eleven translocation 1 Mediated-DNA Hydroxymethylation is Required for Myelination and Remyelination in the Mouse BrainSemantic proximity Read ↗

The Role of 5-Hydroxymethylcytosine in Aging and Alzheimer’s Disease: Current Status and Prospects for Future StudiesSemantic proximity Read ↗

Dynamics of ten‐eleven translocation hydroxylase family proteins and 5‐hydroxymethylcytosine in oligodendrocyte differentiationSemantic proximity Read ↗

Crosstalk between the Methyl-Cytosine Dioxygenase TET3 and the Methyl-CpG-binding protein MECP2 Controls Neuronal MaturationSemantic proximity Read ↗

Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiencySemantic proximity Read ↗

TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice.Semantic proximity Read ↗

MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.