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Article

Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2007

Nguyen Suzanne, Meletis Konstantinos, Fu Dongdong, Jhaveri Sonal, Jaenisch Rudolf

Abstract excerpt

DNA methylation is an epigenetic mechanism involved in gene regulation and implicated in the functioning of the nervous system. The de novo DNA methyltransferase Dnmt3a is expressed in neurons, but its specific role has not been clarified. Dnmt3a is activated around embryonic day 10.5 in mouse ne...

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Identifiers

PMID: 17477386
DOI: 10.1002/dvdy.21176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17477386-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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