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Article

Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase.

Stroke - 1 Nov 1997

Walder C E, Green S P, Darbonne W C, Mathias J, Rae J, Dinauer M C, Curnutte J T, Thomas G R

Abstract excerpt

BACKGROUND AND PURPOSE: Free radicals account for a significant proportion of the brain damage that occurs during ischemic stroke. Using mutant mice (X-CGD) with a dysfunctional phagocytic NADPH oxidase, we investigated the role of this superoxide-generating enzyme as a mediator of the reperfusion injury in a mouse model of middle cerebral artery occlusion. METHODS: Transient (2 hour) middle cerebral artery...

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Identifiers

PMID: 9368573
DOI: 10.1161/01.str.28.11.2252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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