Article

DNA methyltransferase 1 (DNMT1) function is implicated in the age-related loss of cortical interneurons

2020-03-08

Abstract excerpt

Increased life expectancy in modern society comes at the cost of age-associated disabilities and diseases. Aged brains not only show reduced excitability and plasticity, but also a decline in inhibition. Age-associated defects in inhibitory circuits likely contribute to cognitive decline and age-related disorders. Molecular mechanisms that exert epigenetic control of gene expression, contribute to age-associated n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b952b97c-6556-5f7e-a7a7-bee422622737
DOI: 10.1101/2020.03.06.981290

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA methyltransferase 1 (DNMT1) function is implicated in the age-related loss of cortical interneuronsDOI 10.1101/2020.03.06.981290Read

Dnmt1-deficiency in PV interneurons alters cortical circuit function and leads to depression-like behaviorSemantic proximity Read

DNMT3a Deficiency Contributes to Anesthesia/Surgery‐Induced Synaptic Dysfunction and Cognitive Impairment in Aged MiceSemantic proximity Read

The DNA methyltransferase 1 (DNMT1) acts on neurodegeneration by modulating proteostasis-relevant intracellular processesSemantic proximity Read

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.Semantic proximity Read

HIPPOCAMPAL DNA METHYLATION, DNAm AGE AND SPATIAL MEMORY PERFORMANCE IN YOUNG AND OLD RATSSemantic proximity Read

DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopmental disordersSemantic proximity Read

Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan.Semantic proximity Read

DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical NeuronsSemantic proximity Read

Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability.Semantic proximity Read

Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.Semantic proximity Read

Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female miceSemantic proximity Read

A cytosolic function of DNMT1 controls neuronal morphogenesis via microtubule regulationSemantic proximity Read