Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice.

Stroke - 1 Dec 2001

Lee S H, Kim M, Yoon B W, Kim Y J, Ma S J, Roh J K, Lee J S, Seo J S

Abstract excerpt

BACKGROUND AND PURPOSE: Heat-shock proteins (HSPs) are highly conserved proteins that are induced by a variety of stresses. HSP70 is a 70-kDa HSP family known to have cytoprotective effects against various insults. The role of HSP70 in cerebral ischemia remains to be elucidated in vivo. METHODS: To investigate the effect of reduced HSP70 levels on cerebral ischemia, focal cerebral ischemia by intraluminal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Chemistry
Share to Brain Ischemia
Share to Cerebral Infarction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoprotection

Share to Gene Targeting

Share to HSP70 Heat-Shock Proteins

Share to Infarction, Middle Cerebral Artery

Share to Protozoan Proteins

Source

Identifiers

PMID: 11739994
DOI: 10.1161/hs1201.099604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice.PMID 11739994Read ↗

Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein.Semantic proximity Read ↗

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and NeuroprotectionSemantic proximity Read ↗

Identification and Functional Analysis of MicroRNAs in Mice following Focal Cerebral Ischemia InjurySemantic proximity Read ↗

Increased severity of stroke in CB1 cannabinoid receptor knock-out mice.Semantic proximity Read ↗

Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro.Semantic proximity Read ↗

Overexpression of Heat Shock Protein 72 in Transgenic Mice Decreases Infarct Size In VivoSemantic proximity Read ↗

Deficiency of intercellular adhesion molecule 1 attenuates microcirculatory disturbance and infarction size in focal cerebral ischemia.Semantic proximity Read ↗

Minimal ischaemic neuronal damage and HSP70 expression in MF1 strain mice following bilateral common carotid artery occlusion.Semantic proximity Read ↗

STAT1 is activated in neurons after ischemia and contributes to ischemic brain injury.Semantic proximity Read ↗

Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemia.Semantic proximity Read ↗

Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia.Semantic proximity Read ↗

Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.