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Article

Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Apr 1997

Hara H, Fink K, Endres M, Friedlander R M, Gagliardini V, Yuan J, Moskowitz M A

Abstract excerpt

We used transgenic mice expressing a dominant negative mutation of interleukin-1 beta converting enzyme (ICE) (C285G) in a model of transient focal ischemia in order to investigate the role of ICE in ischemic brain damage. Transgenic mutant ICE mice (n = 11) and wild-type littermates (n = 9) were...

Topics

Animals
Brain
Brain Ischemia
Caspase 1
Cerebral Infarction
Cerebrovascular Circulation
Cysteine Endopeptidases
DNA Fragmentation
Gene Expression
Interleukin-1
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Mutation

Nervous System Diseases

Source

Identifiers

PMID: 9143219
DOI: 10.1097/00004647-199704000-00002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9143219-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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