Article
Importance of the gamma-aminobutyric acid(B) receptor C-termini for G-protein coupling.
Molecular pharmacology - 1 May 2002
Grünewald Sylvia, Schupp Bettina J, Ikeda Stephen R, Kuner Rohini, Steigerwald Frank, Kornau Hans-Christian, Köhr Georg
Abstract excerpt
Functional gamma-aminobutyric acid(B) (GABA(B)) receptors assemble from two subunits, GABA(B(1)) and GABA(B(2).) This heteromerization, which involves a C-terminal coiled-coil interaction, ensures efficient surface trafficking and agonist-dependent G-protein activation. In the present study, we took a closer look at the implications of the intracellular C termini of GABA(B(1)) and GABA(B(2)) for G-protein...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Biological Transport
- Cells, Cultured
- Cyclic AMP
- Electrophysiology
- GABA Agonists
- GABA Antagonists
- GTP-Binding Proteins
- Gene Deletion
- Humans