Article
GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.
Nature - 17 Dec 1998
Jones K A, Borowsky B, Tamm J A, Craig D A, Durkin M M, Dai M, Yao W J, Johnson M, Gunwaldsen C, Huang L Y, Tang C, Shen Q, Salon J A, Morse K, Laz T, Smith K E, Nagarathnam D, Noble S A, Branchek T A, Gerald C
Abstract excerpt
The principal inhibitory neurotransmitter GABA (gamma-aminobutyric acid) exerts its effects through two ligand-gated channels, GABA(A) and GABA(C) receptors, and a third receptor, GABA(B) , which acts through G proteins to regulate potassium and calcium channels. Cells heterologously expressing t...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Western
- CHO Cells
- COS Cells
- Cell Line
- Cricetinae
- GABA-B Receptor Agonists
- GABA-B Receptor Antagonists
- Hypothalamus
- Male
- Molecular Sequence Data
- Mutation
- RNA, Messenger