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Article

Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Aug 2011

Laviv Tal, Vertkin Irena, Berdichevsky Yevgeny, Fogel Hilla, Riven Inbal, Bettler Bernhard, Slesinger Paul A, Slutsky Inna

Abstract excerpt

Presynaptic inhibition via G-protein-coupled receptors (GPCRs) and voltage-gated Ca(2+) channels constitutes a widespread regulatory mechanism of synaptic strength. Yet, the mechanism of intermolecular coupling underlying GPCR-mediated signaling at central synapses remains unresolved. Using FRET spectroscopy, we provide evidence for formation of spatially restricted (<100 Å) complexes between GABA(B) receptors...

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Identifiers

PMID: 21880914
DOI: 10.1523/JNEUROSCI.1527-11.2011
PMCID: PMC6703276

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