Article
The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors.
Biochemical pharmacology - 15 Oct 2004
Thuault Seb J, Brown Jon T, Sheardown Steven A, Jourdain Sabine, Fairfax Benjamin, Spencer Jonathan P, Restituito Sophie, Nation Josephine H L, Topps Stephanie, Medhurst Andrew D, Randall Andrew D, Couve Andres, Moss Stephen J, Collingridge Graham L, Pangalos Menelas N, Davies Ceri H, Calver Andrew R
Abstract excerpt
Studies in heterologous systems have demonstrated that heterodimerisation of the two GABA(B) receptor subunits appears to be crucial for the trafficking and signalling of the receptor. Gene targeting of the GABA(B1) gene has demonstrated that the expression of GABA(B1) is essential for GABA(B) receptor function in the central nervous system (CNS). However, the contribution of the GABA(B2) subunit in the formation...
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