Article
Ligand-induced signal transduction within heterodimeric GABA(B) receptor.
Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001
Margeta-Mitrovic M, Jan Y N, Jan L Y
Abstract excerpt
gamma-aminobutyric acid type B (GABA(B)) receptors, G protein-coupled receptors (GPCRs) for GABA, are obligate heterodimers of two homologous subunits, GB1 and GB2. Typical for family C GPCRs, the N termini of both GB1 and GB2 contain a domain with homology to bacterial periplasmic amino acid-binding proteins (PBPs), but only the GB1 PBP-like domain binds GABA. We found that both GB1 and GB2 extracellular N...
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