Article
Functional and structural basis of a negative allostery within GABAB hetero-tetramers.
Nature communications - 20 Mar 2026
Shen Cangsong, Ding Hongyang, Zhang Shenlan, Xu Chanjuan, Zou Binqian, Ji Suyu, Liu Yi-Ru, Li Yizhong, Zhou Rui, Liang Jiayin, Shen Dan-Dan, Liu Yuxuan, Chen Xuan, Rondard Philippe, He Jun, Zhang Yan, Pin Jean-Philippe, Liu Jianfeng
Abstract excerpt
G protein coupled receptors (GPCRs) oligomerization may allow signal integration from different GPCR units. The GABAB receptor, activated by the main inhibitory transmitter, GABA, is an obligatory heterodimer. It is the target of two therapeutic drugs, baclofen and GHB, and can form stable oligomers. The existence, roles, and possible allosteric interaction of GABAB oligomers remain elusive. Here, we show that...
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