Article
A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance.
Pharmacogenetics - 1 Jun 2002
Conrad Silke, Kauffmann Hans-Martin, Ito Ken-ichi, Leslie Elaine M, Deeley Roger G, Schrenk Dieter, Cole Susan P C
Abstract excerpt
The human 190 kDa multidrug resistance protein, MRP1, is a polytopic membrane glycoprotein that confers resistance to a wide range of chemotherapeutic agents. It also transports structurally diverse conjugated organic anions, as well as certain unconjugated and conjugated compounds, in a reduced glutathione-stimulated manner. In this study, we characterized a low-frequency (<1%) naturally occurring mutation in...
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