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Article

ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.

Pharmacogenomics - 1 Feb 2001

Kerb R, Hoffmeyer S, Brinkmann U

Abstract excerpt

Transport by ATP-dependent efflux pumps, such as P-glycoprotein (PGP) and multi-drug resistance related proteins (MRPs), influences bioavailability and disposition of drugs. These efflux pumps serve as defence mechanisms and determine bioavailability and CNS concentrations of many drugs. However, despite the fact that substantial data have been accumulated on the structure, function and pharmacological role of...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Source

Identifiers

PMID: 11258197
DOI: 10.1517/14622416.2.1.51

Genes

PGP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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