Article
Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck.
Cancer research - 1 Oct 1994
Zhang S Y, Klein-Szanto A J, Sauter E R, Shafarenko M, Mitsunaga S, Nobori T, Carson D A, Ridge J A, Goodrow T L
Abstract excerpt
Sixty-eight primary head and neck squamous cell carcinomas and nine head and neck squamous cell carcinoma cell lines were examined for mutations and homozygous deletions of the p16/CDKN2 gene. Homozygous deletions of the p16/CDKN2 gene were found in three lines, and a mutation was detected in another cell line. In contrast, none of the primary tumors showed homozygous deletions and 11 of 68 tumors had missense or...
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