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Article

Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates.

Antimicrobial agents and chemotherapy - 1 Apr 2001

Roychoudhury S, Catrenich C E, McIntosh E J, McKeever H D, Makin K M, Koenigs P M, Ledoussal B

Abstract excerpt

The activity of three new, 8-methoxy-nonfluorinated quinolones (NFQs) against multiple-drug-resistant staphylococci was investigated. First, using Staphylococcus aureus strains containing point mutations in the serine 84-80 hot spots of the target genes (gyrA and grlA), cell growth inhibition potencies of the NFQs as a result of DNA gyrase and topoisomerase IV inhibition were estimated and compared with those of...

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Identifiers

PMID: 11257024
DOI: 10.1128/AAC.45.4.1115-1120.2001
PMCID: PMC90433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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