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Article

In vitro development of resistance to a novel fluoroquinolone, DW286, in methicillin-resistant Staphylococcus aureus clinical isolates.

The Journal of antimicrobial chemotherapy - 1 Apr 2003

Kim Mi-Jeong, Yun Hee-Jeong, Kang Jin-Wook, Kim Sunghoon, Kwak Jin-Hwan, Choi Eung-Chil

Abstract excerpt

In vitro development of resistance to a novel fluoroquinolone, DW286, as well as to ciprofloxacin, gemifloxacin, sparfloxacin and trovafloxacin, was investigated in eight methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. The strains were subcultured in subinhibitory concentrations of each agent during a 50 day period. Subculturing in most agents led to the selection of 37 mutants with...

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PMID: 12654771
DOI: 10.1093/jac/dkg162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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