Bacterial resistance to quinolones: mechanisms and clinical importance.

doi:10.1093/clinids/11.supplement_5.s960

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Article

Bacterial resistance to quinolones: mechanisms and clinical importance.

Reviews of infectious diseases - 1 Jan 2000

Wolfson J S, Hooper D C

Abstract excerpt

An overview of bacterial resistance to new quinolones is presented with a consideration of mechanisms, clinical importance, and approaches to suppression of the emergence of resistance. Single-step mutation to high-level resistance occurs at a frequency of less than or equal to 10(-10) for many b...

Topics

4-Quinolones
Anti-Infective Agents
Bacteria
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Escherichia coli
Microbial Sensitivity Tests
Mutation

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