Article
Generation of protein lineages with new sequence spaces by functional salvage screen.
Protein engineering - 1 Sept 2001
Kim G J, Cheon Y H, Park M S, Park H S, Kim H S
Abstract excerpt
A variety of different methods to generate diverse proteins, including random mutagenesis and recombination, are currently available and most of them accumulate the mutations on the target gene of a protein, whose sequence space remains unchanged. On the other hand, a pool of diverse genes, which is generated by random insertions, deletions and exchange of the homologous domains with different lengths in the...
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