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Directed evolution through DNA shuffling for the improvement and understanding of genes and promoters.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011

Werkman Joshua R, Pattanaik Sitakanta, Yuan Ling

Abstract excerpt

Unlike rational protein engineering, directed evolution provides an a priori approach toward the engineering of improved proteins and novel promoters. This minimally recursive technique builds upon small improvements by selecting and combining the best changes. Protein-protein/DNA interactions, catalytic efficiency, or resilience to inhibitors can be improved by thousands of times. By working within a subspace of...

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PMID: 21720962
DOI: 10.1007/978-1-61779-154-3_19

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