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Article

Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length.

The Journal of biological chemistry - 19 Dec 2003

Jonassen Tanya, Davis Diana E, Larsen Pamela L, Clarke Catherine F

Abstract excerpt

Caenorhabditis elegans clk-1 mutants lack coenzyme Q9 and accumulate the biosynthetic intermediate demethoxy-Q9. A dietary source of ubiquinone (Q) is required for larval growth and development of the gonad and germ cells. We considered that uptake of the shorter Q8 isoform present in the Escherichia coli food may contribute to the Clk phenotypes of slowed development and reduced brood size observed when the...

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PMID: 14530273
DOI: 10.1074/jbc.M308760200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length.PMID 14530273Read ↗

Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria.Semantic proximity Read ↗

Coenzyme Q supports distinct developmental processes in Caenorhabditis elegans.Semantic proximity Read ↗

Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes.Semantic proximity Read ↗

Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q.Semantic proximity Read ↗

Ubiquinone is necessary for Caenorhabditis elegans development at mitochondrial and non-mitochondrial sites.Semantic proximity Read ↗

Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation.Semantic proximity Read ↗

The effect of different ubiquinones on lifespan in Caenorhabditis elegans.Semantic proximity Read ↗

C. elegans knockouts in ubiquinone biosynthesis genes result in different phenotypes during larval development.Semantic proximity Read ↗

The role of DMQ(9) in the long-lived mutant clk-1.Semantic proximity Read ↗

Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.Semantic proximity Read ↗

Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity.Semantic proximity Read ↗

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