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Article

Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria.

The Journal of biological chemistry - 22 Nov 2002

Jonassen Tanya, Marbois Beth N, Faull Kym F, Clarke Catherine F, Larsen Pamela L

Abstract excerpt

The Caenorhabditis elegans clk-1 mutants lack coenzyme Q(9) and instead accumulate the biosynthetic intermediate demethoxy-Q(9) (DMQ(9)). clk-1 animals grow to reproductive adults, albeit slowly, if supplied with Q(8)-containing Escherichia coli. However, if Q is withdrawn from the diet, clk-1 animals either arrest development as young larvae or become sterile adults depending upon the stage at the time of the...

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PMID: 12324451
DOI: 10.1074/jbc.M204758200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria.PMID 12324451Read ↗

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Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes.Semantic proximity Read ↗

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Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.Semantic proximity Read ↗

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Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.Semantic proximity Read ↗

Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity.Semantic proximity Read ↗

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