Article
Association of E-cadherin germ-line alterations with prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2001
Ikonen T, Matikainen M, Mononen N, Hyytinen E R, Helin H J, Tommola S, Tammela T L, Pukkala E, Schleutker J, Kallioniemi O P, Koivisto P A
Abstract excerpt
In our recent cancer registry-based study, the incidence of gastric carcinoma was increased up to 5-fold in male relatives of early-onset prostate cancer (PCA) patients. This association may reflect the influence of genetic factors predisposing individuals to both tumor types. Germ-line mutations of the CDH1 gene at 16q have recently been associated with familial gastric cancer. Furthermore, two genome-wide...
Topics
- Adaptor Proteins, Signal Transducing
- Aged
- Aged, 80 and over
- Cadherins
- Carrier Proteins
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Mutational Analysis
- DNA, Neoplasm
- Family Health
- Female