Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CHEK2 variants associate with hereditary prostate cancer.

British journal of cancer - 17 Nov 2003

Seppälä E H, Ikonen T, Mononen N, Autio V, Rökman A, Matikainen M P, Tammela T L J, Schleutker J

Abstract excerpt

Recently, variants in CHEK2 gene were shown to associate with sporadic prostate cancer in the USA. In the present study from Finland, we found that the frequency of 1100delC, a truncating variant that abrogates the kinase activity, was significantly elevated among 120 patients with hereditary prostate cancer (HPC) (four out of 120 (3.3%); odds ratio 8.24; 95% confidence interval 1.49-45.54; P=0.02) compared to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Replication
Share to Checkpoint Kinase 2
Share to Epidemiologic Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Finland

Share to Fungal Proteins

Share to Genes, Tumor Suppressor

Share to Prostatic Neoplasms

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 14612911
DOI: 10.1038/sj.bjc.6601425
PMCID: PMC2394451

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHEK2 variants associate with hereditary prostate cancer.PMID 14612911Read ↗

A novel founder CHEK2 mutation is associated with increased prostate cancer risk.Semantic proximity Read ↗

CHEK2*1100delC is not an important high-risk gene in families with hereditary prostate cancer in southern Sweden.Semantic proximity Read ↗

A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancerSemantic proximity Read ↗

<i>CHEK2</i><b><sup>∗</sup></b>1100delC Mutation and Risk of Prostate CancerSemantic proximity Read ↗

Increased risk of breast cancer associated with CHEK2*1100delC.Semantic proximity Read ↗

Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2*1100delC Heterozygotes Estimated From the Copenhagen General Population Study.Semantic proximity Read ↗

ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer.Semantic proximity Read ↗

Analysis of familial male breast cancer for germline mutations in CHEK2.Semantic proximity Read ↗

Limited relevance of the CHEK2 gene in hereditary breast cancer.Semantic proximity Read ↗

Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial studySemantic proximity Read ↗

Mutations in CHEK2 associated with prostate cancer risk.Semantic proximity Read ↗

Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in proband.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.