Article
Allelic imbalance in familial and sporadic prostate cancer at the putative human prostate cancer susceptibility locus, HPC1. CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group.
British journal of cancer - 1 Dec 1998
Dunsmuir W D, Edwards S M, Lakhani S R, Young M, Corbishley C, Kirby R S, Dearnaley D P, Dowe A, Ardern-Jones A, Kelly J, Eeles R A
Abstract excerpt
A recent report has provided strong evidence for a major prostate cancer susceptibility locus (HPC1) on chromosome 1q24-25 (Smith et al, 1996). Most inherited cancer susceptibility genes function as tumour-suppressor genes (TSGs). Allelic loss or imbalance in tumour tissue is often the hallmark of a TSG. Studies of allelic loss have not previously implicated the chromosomal region 1q24-25 in prostate cancer....
Topics
- Aged
- Alleles
- Chromosomes, Human, Pair 1
- Genes, Tumor Suppressor
- Genetic Markers
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Neoplastic Syndromes, Hereditary
- Prostatic Neoplasms