Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNP.

doi:10.1007/s00439-005-0060-6

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Article

Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNP.

Human genetics - 1 Dec 2005

Lindström Sara, Wiklund Fredrik, Jonsson Björn-Anders, Adami Hans-Olov, Bälter Katarina, Brookes Anthony J, Xu Jianfeng, Zheng S Lilly, Isaacs William B, Adolfsson Jan, Grönberg Henrik

Abstract excerpt

The E-cadherin gene (CDH1) has been proposed as a prostate cancer (PC) susceptibility gene in several studies. Aberrant protein expression has been related to prognosis and progression in PC. In addition, a functional promoter SNP (rs16260) has been found to associate with PC risk. We performed a comprehensive genetic analysis of CDH1 by using the method of haplotype tagged SNPs in a large Swedish...

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PMID: 16189707
DOI: 10.1007/s00439-005-0060-6

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CDH1

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